Now contains Metafolin®, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF), as well as 1000 IU of vitamin D3 per serving.
5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health, as it participates as a cofactor in a reaction that involves the remethylation of homocysteine to methionine. Unlike synthetic folic acid, 5-MTHF can be used directly by the body without the need for an additional conversion via the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR).
In certain populations, the body's ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.
Metafolin® contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier.
Additional vitamin D3 (also known as cholecalciferol) has been added to this formula, as numerous scientists now feel that supplementation with vitamin D at levels greater than previously thought necessary is critical to helping maintain overall health.
Adults take 8 vegetarian capsules daily or as directed by a healthcare professional.
This product is best taken with meals in divided doses, such as 4 capsules with the 2 largest meals of the day.